The five senses we use to perceive our environment are hearing, sight, smell, taste and touch. David Julius discovered molecular mechanisms by which the sense of touch allows us to perceive pain and temperature.
The ability to detect painful stimuli is essential to our health and survival as it allows us to avoid direct contact with agents that can produce injury. Following injury, the skin becomes hypersensitive and even light touches or warm temperatures can be painful. This hypersensitivity has the positive function of protecting the skin from further injury. However, it sometimes has a negative outcome, causing the development of chronic pain syndromes that can be physiologically and psychologically devastating. In pioneering studies conducted over the past fifteen years, David Julius and his coworkers have uncovered mechanisms by which we sense pain and temperature as well as mechanisms that underlie pain hypersensitivity. His work has provided insights into fundamental mechanisms underlying the sense of touch and opened the door to rational drug design for the treatment of chronic pain syndromes.
大卫・朱利雅斯 (David Julius)
大卫・朱利雅斯 (David Julius) 1955 年出生於美国纽约布莱顿海滩，现任美国加州大学三藩市分校生理学系主任及教授。1977 年美国麻省理工学院学士学位毕业，1984 年获美国加州大学伯克莱分校博士学位，其后 1990 年加入 UCSF 任教，是美国国家科学院和美国国家文理学院院士。
2010 年5月27日 香港