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大卫・朱利雅斯

以表彰他对人类皮肤感知疼痛、刺激和温度以至产生疼痛、过敏现象背后的分子机制的开创性发现。

贡献

人类对周围环境的感知有听觉、视觉、嗅觉、味觉和触觉等五种。大卫・朱利雅斯(David Julius)发现了有关的分子机制,使人类可以通过触觉,感知疼痛,温度和其他相关感觉。

人类能感觉疼痛,从而避开伤害,维持健康,甚至保障生命。创伤发生后,皮肤变得过敏,即使轻微的触摸或暖和的温度都足以产生疼痛感觉。这种过敏作用保护皮肤不再受损;但却可能发展成为慢性痛症,打击病人的身心健康。

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得奖人获奖介绍

The five senses we use to perceive our environment are hearing, sight, smell, taste and touch.  David Julius discovered molecular mechanisms by which the sense of touch allows us to perceive pain and temperature.

The ability to detect painful stimuli is essential to our health and survival as it allows us to avoid direct contact with agents that can produce injury. Following injury, the skin becomes hypersensitive and even light touches or warm temperatures can be painful.  This hypersensitivity has the positive function of protecting the skin from further injury.  However, it sometimes has a negative outcome, causing the development of chronic pain syndromes that can be physiologically and psychologically devastating. In pioneering studies conducted over the past fifteen years, David Julius and his coworkers have uncovered mechanisms by which we sense pain and temperature as well as mechanisms that underlie pain hypersensitivity.  His work has provided insights into fundamental mechanisms underlying the sense of touch and opened the door to rational drug design for the treatment of chronic pain syndromes.

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得奖者简介
大卫・朱利雅斯 (David Julius)

大卫・朱利雅斯 (David Julius) 1955 年出生於美国纽约布莱顿海滩,现任美国加州大学三藩市分校生理学系主任及教授。1977 年美国麻省理工学院学士学位毕业,1984 年获美国加州大学伯克莱分校博士学位,其后 1990 年加入 UCSF 任教,是美国国家科学院和美国国家文理学院院士。

得奖人自传
得奖者特写
2010年度邵逸夫生命科学与医学奖讲座