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2005年 生命科学与医学奖

迈克尔・贝里奇

为表彰他发现调控细胞的运作中钙的关键作用。

 

得奖人简介

迈克尔・贝里奇

贡献 / 得奖人获奖介绍

The discovery of calcium-mediated signalling pathways in the regulation of cellular function has truly revolutionized the fields of life science and medicine. The knowledge gained on how various factors increase calcium mobilization and how calcium controls cellular activity has widely expanded the areas of cell and molecular biology, and has led to the development of novel therapeutic strategies ranging from the treatment of heart disease to the improvement of learning and memory. These discoveries represent one of the most important cell signalling pathways in biology and have changed forever the way we think about prevention and treatment of disease.

Cellular communication occurs through chemical signals such as hormones, neurotransmitters and nitric oxide, which act via specific receptors or receptive molecules and are linked to diverse intracellular and extracellular signalling pathways. Berridge's major achievement was to discover one such pathway that is linked to the hydrolysis of inositol lipids. This signalling system liberates two key second messengers, namely, IP3 (inositol 1,4,5-trisphosphate) and DAG (diacylglycerol). IP3 was discovered by Berridge, who showed that it functioned to release calcium from internal stores. This IP3/Ca2+ signalling system is of fundamental importance in regulating diverse cellular processes such as muscle contraction, cell growth and differentiation, secretion, fertilization, synaptic plasticity and information processing.

 

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得奖人简介

Michael Berridge

迈克尔・贝里奇

(Michael Berridge ) (1938-2020)

迈克尔・贝里奇 (Michael Berridge ) (1938年出生) 现为英国剑桥大学细胞信号荣誉教授,曾任剑桥巴布拉汉研究所 (Babraham Institute) 副首席科学家直至2003年,后获委任该院首位荣休院士,继续细胞信号方面的研究。

迈克尔爵士1960年於罗德西亚之罗德西亚与尼亚萨兰大学一级荣誉理学士毕业,1965年取得英国剑桥大学哲学博士。

迈克尔爵士1972年获选英国圣三一皇家学院(Trinity College)院士,1984年获选皇家学会院士和1999年选为美国科学院外籍院士。



2005年6月3日 香港

 

迈克尔爵士二零二零年二月十三日在英国家中离世。

 

得奖人自传

 

 

 

 

得奖人特写

 

2005年度邵逸夫生命科学与医学奖讲座

"Calcium Signalling in Health and Disease"由迈克尔 • 贝里奇爵士主讲