Biographical Note of Professor Bruce A BEUTLER

Professor Bruce Beutler is a Regental Professor and Director of the Center for the Genetics of Host Defense at UT Southwestern Medical Center in Dallas, Texas. He received his medical training at the University of Chicago, graduating in 1981. As a postdoctoral fellow at The Rockefeller University (1983-1986), he isolated mouse tumor necrosis factor (TNF) and discovered its importance as a mediator of inflammation. Subsequently, at UT Southwestern, he analyzed mammalian responses to bacterial lipopolysaccharide. This work culminated in the identification of Toll-like receptors as key sensors of the innate immune system, used to detect infection. In further studies, Beutler employed a forward genetic strategy to elucidate many aspects of mammalian immunity.  
 
He has received numerous awards for his work including the Balzan Prize (2007), the Albany Medical Center Prize (2009), the Shaw Prize (2011), and election to both the US National Academy of Sciences and the Institute of Medicine (2008). In 2011, he shared the Nobel Prize in Physiology or Medicine for “discoveries concerning the activation of innate immunity”.